4J

Non-infectious disease

Causes of non-infectious disease including genes, lifestyle, diet and the environment, how cancer develops from mutations, benign and malignant tumours, skin cancer and smoking in Australia, rheumatic heart disease, and how research and public health campaigns reduce disease.

About two in every three Australians will be diagnosed with some form of skin cancer by the age of 70. Australia and New Zealand have the highest rates of melanoma in the world. Yet most of these cancers could be prevented by a hat, a shirt and some sunscreen.

Diseases you can't catch

Non-infectious diseases are not caused by pathogens and can't spread from person to person. In Australia they cause most deaths: heart disease, dementia, stroke, lung cancer and diabetes are all near the top of the list. Many are chronic, meaning they last a long time, often for life. Most have more than one cause.

CauseExamples
Genetic: a faulty gene or chromosome, usually inheritedCystic fibrosis (about 1 in 2500 Australian babies), haemophilia, Down syndrome; some genes raise the risk of breast and bowel cancer
Lifestyle: choices and habitsSmoking (lung cancer, heart disease), too little exercise and a high-energy diet (type 2 diabetes, heart disease), too much alcohol (liver disease), sunburn (skin cancer)
Diet: deficienciesScurvy (vitamin C), goitre (iodine, 4D), anaemia (iron, 4G), rickets (vitamin D)
Environmental: things in our surroundingsAsbestos (mesothelioma), air pollution (asthma), UV and other radiation (cancers)
Ageing and wearDementia, osteoarthritis, many cancers

Asbestos is a mineral once used widely in Australian houses and was mined at Wittenoom in Western Australia until 1966. Breathing in its tiny fibres can cause a cancer of the lining of the lungs called mesothelioma, often 20 to 50 years later. Australia has one of the highest rates of mesothelioma in the world, and all use of asbestos was banned in 2003. Old asbestos sheeting should only be removed by licensed workers.

How cancer starts

Your cells divide to grow and to replace worn-out cells. Genes control when a cell divides and when it stops. Each time a cell copies its DNA, there is a small chance of a mistake, a mutation. Mutations can also be caused by mutagens such as UV light, chemicals in tobacco smoke and X-rays.

Most mutations do no harm, and cells have ways of repairing damaged DNA or destroying themselves if it can't be fixed. The immune system also kills many abnormal cells. But if a cell builds up mutations in several of the genes that control division, it can start dividing over and over without stopping. That is cancer. Because several mutations are usually needed, most cancers take years to develop, and the risk rises steeply with age.

A benign tumour stays in one place. A malignant tumour invades nearby tissue and can spread through blood vessels.
  • A benign tumour grows slowly in one place, often inside a capsule, and doesn't spread. It may still need to be removed if it presses on something important, such as the brain.
  • A malignant tumour is cancer. It invades the tissue around it, and cells can break off and travel in the blood or lymph to start new tumours elsewhere. This spread is called metastasis, and it is what makes cancer so dangerous.
InteractiveHow cancer builds up
Try this
  • Live a life with no risk factors. Watch the cells collect mutations as they divide. At what age, if any, does a cell become cancerous?
  • Run 100 lives with no risk factors and note how many develop cancer and the average age. Then turn on "Lots of sunburn / UV" and run 100 lives again.
  • Try smoking, then both UV and smoking. How do the numbers change?
  • Turn on "Inherited faulty gene" with everything else off. Why do people with an inherited faulty gene often get cancer at a younger age?

Treating cancer

Cancers are treated with surgery to remove the tumour, radiotherapy (beams of high-energy radiation aimed at the tumour), and chemotherapy (drugs that kill rapidly dividing cells). Because chemotherapy also affects normal fast-dividing cells, side effects include hair loss and a weakened immune system. Newer immunotherapy drugs help the patient's own immune system recognise and attack cancer cells. Finding cancer early makes a huge difference, which is why Australia runs free screening programs for bowel, breast and cervical cancer.

Two Australian success stories

Sun protection. In 1981 the Cancer Council launched the "Slip! Slop! Slap!" campaign, with a cartoon seagull telling Australians to slip on a shirt, slop on sunscreen and slap on a hat. "Seek shade" and "slide on sunglasses" were added later. Australian schools adopted "no hat, no play" rules, and melanoma rates in younger Australians have since started to fall. The UV index is now shown in weather forecasts; protection is recommended whenever it is 3 or above, which in most of Australia is most of the year.

Smoking. A large Australian study found that up to two in every three long-term smokers die from a disease caused by smoking. Through advertising bans, tax increases, smoke-free laws and graphic warnings, the share of Australian adults who smoke daily has fallen from about one in three in 1980 to around one in ten. In 2012, Australia became the first country in the world to require plain packaging on cigarettes. The newest challenge is vaping: e-cigarettes deliver highly addictive nicotine, and since 2024 they have only been legal in Australia from pharmacies.

Disease, research and fairness

Some diseases fall hardest on particular communities. Rheumatic heart disease starts with an ordinary infection: a strep throat or infected skin sores caused by group A streptococcus bacteria. In some people the immune response to the bacteria also attacks the valves of the heart, scarring them permanently. The disease itself is not infectious, and it has almost disappeared from wealthy communities. Yet First Nations children and young adults in some remote communities in northern and central Australia have some of the highest rates in the world. The causes include crowded housing, which helps the bacteria spread, and limited access to clinics. Researchers, health services and Aboriginal community-controlled organisations are working on better housing, early diagnosis with portable heart scans, regular penicillin injections to prevent repeat attacks, and a vaccine against group A strep. It is a clear example of how health depends on living conditions as well as on biology.

Test yourself

  1. Which of these is a non-infectious disease?

  2. What makes a malignant tumour more dangerous than a benign one?

  3. Why does the risk of most cancers increase with age?

  4. Which is an example of a mutagen?

Name the two kinds of tumour.

Benign tumourstays in one place, often enclosedcapsule of tissue around itMalignant tumour (cancer)invades tissue and spreadsblood vessel

What is the main cause of each disease?

A change in a cell's DNA is called a . When cancer cells spread to other parts of the body, it is called . Drugs that kill rapidly dividing cells are called . A long-lasting disease is described as . Mesothelioma is caused by breathing in fibres.

4 marks

Explain why sunburn in childhood increases the risk of skin cancer later in life, and evaluate the "Slip! Slop! Slap!" campaign as a way to reduce it.